Igikoko c'umukaraba: Gufungura ubuhinga bwa siyansi bwo mu kanwa "Super-Photon" Licochalcone A yo kwera

"Urukoba rwiza runyegeza amakosa ijana; urukoba rwirabura rwonona vyose."

Kubera ko ari rimwe mu masoko nyamukuru y’isi yose y’ibikoresho vyo kwisiga mu kanwa, ubunini bw’isoko ry’Ubushinwa ryitezwe gushika ku 100.000.25.57 miliyari RMB muri 2025, itera imbere gushika aho iba isoko rinini kuruta ayandi yose kw’isi rifise .3.8% igipimo c'iterambere ry'umwaka.
Mu bijanye n’ubwiza bw’akanwa mu Bushinwa,Urutonde rwo kwera ruriko rurakura cane. Nk’akarorero, kuri JD.com mu 1990.igice ca mbere ca 2025(Ishusho ya 1),SKUs nshasha zirenga 3.500vyatangujwe mu gice co kwera-ni nk'ibice 90 kw'ijana vy'ibikoresho vyose bishasha vyo kwisiga mu kanwamu kiringo nyene, birenze kure n'iyo ibindi bice bitobito nk'ivyo kurwanya-ugukura, gutera amazi mu mubiri, no kurwanya-ugutakaza umushatsi[1].

Guhindura ibirungo vy'ukwera bihuye cane-Ibintu bishasha birakenewe cane

Ibirungo nyamukuru vyo kwera mu kanwa ubu biri kw’isoko ni .glutatiyoni, ergotiyoni, kandiinyanya yera. Ivyo bibiri vya mbere vyibanda canecane ku vyerekeye .gukingira umubiri n'ugukuraho imigera, mu gihe iyo ya nyuma ishimika ku .gukingira amashushoinyungu (Imbonerahamwe 1).

Ariko rero, amabara y’ingero zose ariko arashikirwa n’urushe rw’ivyiyumviro. Ibintu vyo kwera biriko birarushiriza gusa mu bijanye no guhitamwo ibirungo, ivyo bikaba bituma abaguzi batagikunda ivyo vyiyumviro vy’agaciro bisubiramwo. Isoko ririko rikeneye vyihutirwa .ibikorwa bishasha vyo kwera akanwakugira ngo bashire inguvu nshasha mu rwego rw’ubwiza bwo mu kanwa buhagaze.

Inyishu y’ico kibazo yoshobora kuba iri mu .Urwego rw'ivyo kwisiga.

Kubera ko "ivyo kwisiga n'ivyo kurya" vyateye imbere, urwego rwo kwitaho urukoba rwatumye habaho ivyiyumviro vyinshi vy'ibirungo vy'ubwiza bwo mu kanwa.Ergotiyonivyakomotse ku gishushanyo ca Helena RubinsteinUmugozi w'umwiraburacream (Ishusho ya 2), iyo Later Lift yahinduye igikoresho cayo co mu kanwa citwa "Ice Crystal Skin" (Ishusho ya 3). Iciyumviro caasitazantiyavuye muri PROYAAnti kabiriumurongo (Ishusho ya 4), ukurikirwa n’uwa Me Today .Irasa ry'umuco(Ishusho ya 5).

Igikurikira gishobora kuba inyenyeri,Igikoko, ikomoka kuri Guyu .Auroraurutonde (Ishusho ya 6). Uwo murongo wo kwera, wari ushimikiye kuri glabridin, warafashije Guyu gushika ku .5 miliyaridi RMB muri GMV. Nk’uko ari ikigo gihambaye c’Ubushinwa co kwitaho urukoba cubatswe ku glabridin, Guyu yerekanye iterambere rikomeye cane rirengeye cane ibigo vyo mu gihugu nka PROYA na Kans.

Ariko rero, mu vyo mu rugo .ubwiza bwo mukanwasector, glabridin iguma ahanini itakoreshwa-irema akaryo gashasha gahambaye ku bimenyetso vy’ubwiza bwo mu kanwa.

Ibishushanyo 2 na 3: Umugozi w’umwirabura wa Helena Rubinstein n’urukoba rw’ikibiriti c’urubura rwa Helena Rubinstein (rurimwo ergothioneine)

Ibishushanyo 4 & 5: PROYA Anti ibiri na jewe uno musi (irimwo astaxanthin)

Igishushanyo ca 6: Urutonde rw’ivyatsi vy’i Guyu Aurora (vyakozwe n’umuti witwa glabridin)

Uburyo bwa Licorice mu kwera urukoba

Licorice ifise amateka maremare yo gukoreshwa mu guteka no mu kuvura mu Bushinwa kandi ifatwa nk’ikabiri-koresha ivyokurya–imitiikirungo. Mu buryo bwa kera bw'ubwiza bw'Abashinwa"San Bai Gan Cao Tang", licorice ifatanijwe n’ibimera vyitwa Atractylodes, White Peony, na Poria kugira ngo bifashe mu guhangana n’ingorane z’urukoba nk’ugutera ibara ryinshi, gutera ibara ry’urukoba, ukugira ibara ry’agahama, n’ukugira urukoba rwumye. Licorice na yo iri mu miti izwi cane yo kwera nk’"Yu Rong San"kandi"Yu Nü Tao Hua Fen."

Ubushakashatsi bwo muri iki gihe bwerekana ko licorice irimwo ibintu bikora neza nk’gilisirizini, aside ya gilisiretini, kandiIgikoko, ivyo bikaba bigira ico bikoze neza ku ntungamubiri zitwa melanocytes zishikiwe n’ivyago vy’amafoto, umubabaro w’ivy’umubiri, n’ibintu bitera umururumba-bigabanya ubushobozi bwo gukora melanine birenze urugero. Vyongeye, igiti citwa licorice gishobora kugabanya urugero rwa melanine ku .guhagarika tirosinase, ari yo enzyme nyamukuru ifasha mu gutuma umuntu agira ibara ry’urukoba.

"Igikoresho co mu kanwa gikomeye cane" - Glabridin

Hari ubwoko bwinshi bw’ivyatsi vy’umukara, kandi bitatu ni vyo vyemewe gukoreshwa mu Bushinwa:Gilisiriza uralensis, Glycyrhiza ivyuka, kandiIgikoko c'umubiri. Igikoko, ikintu kidasanzwe gikora ku mubiri kiboneka gusa mu 1914.Igikoko c'umubiri, bisaba imyaka myinshi y’ukukura kugira ngo vyirundanirizwe kandi mu bisanzwe bibaho ku rugero ruto cane.
KuvaIbiro 1.000 vy'ibiterwa vya G. glabra, gusank'ikiro 0,1 c'umuti witwa glabridinebirashobora gukurwamwo-igipimo co gukugwamwo 1:10,000 kigaragaza ukuntu ari kidasanzwe.

Muri ico gihe nyene, glabridin yerekana .ubushobozi bukomeye bwo kwera, bikaba vyatumye imenyekana ko ari ."ibirungo vy'amafoto vy'akanwa". Yaramaze gukundwa cane mu bijanye n’ivy’urukoba kandi irakoreshwa cane n’ibigo bikomeye vy’ubwiza.

Igitera Tirosinase gikomeye**

Uretse ubushobozi bwayo bwo gukingira umubiri n’ubushobozi bwo kurwanya-umururumba, ubushobozi budasanzwe bwa glabridin buri muingaruka zikomeye zibuza tyrosinase. Mu bimera vyose bizwi bikomoka ku bimera-, birafise ababirwanya bake, kandi inkomezi zavyo zo kubuza ni .hejuru canekuruta imiti ikoreshwa cane mu guhagarika tyrosinase nk’Aside ya kojikikandiarbutini.

Dushingiye ku bushakashatsi bwasohowe [2], glabridin ikora nk’umuti witwa .irembo ry'amamolekule-ugufunga, bikaba bibuza abantu gushika mu kibanza gitera tyrosinase. Mu kubuza tyrosine kwinjira mu kibanza gikora maze igahinduka mu nyuma, glabridin irakora neza .bihagarika ugukorana kwa melanine aho ikomoka.

Igishushanyo ca 8:
I: Iyo glabridine itahari, tyrosine (ubururu bwijimye) irashobora kwinjira mu gice c’imbere c’umubiri (ubururu buzize) maze buhoro buhoro igahinduka melanine.
B: Iyo hariho glabridine (ibara ry’icatsi kibisi), ubwinjiriro bw’aho ivyuma bitera umuriro burazibirwa, bigatuma tyrosine idashobora kwinjira.

Dushingiye ku makuru y’igerageza yatanzwe n’ikigo ca gatatu[{0}}[4], igikorwa co guhagarika tyrosinase ca Licochalcone A n’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi bisa n’ivyo. Iryo gerageza ryakoresheje igice-ivy’uburemere bwo guhagarika (IC50) bwa tyrosinase nk’ikigereranyo co gusuzuma. Ico kigereranyo kigereranya ivyiyumviro vy’ibikoresho vya mbere bisabwa kugira ngo bibuze 50% vy’ibikorwa vya tyrosinase. Agaciro ka IC50 kari hasi kerekana ko igikoresho gishasha kigaragaza ingaruka zikomeye zo guhagarika iyo gifise ivyiyumviro bike, bikaba vyerekana ko gishobora guhagarika cane tyrosinase.

Kugira ngo habeho ubutungane, iryo gerageza ryaciwemwo imigwi ibiri y’ukugereranya:

Itsinda rya 1: High-purity raw materials (purity >98%), harimwo Licochalcone A, glutathione, ergothioneine, n’aside ya kojic (igenzura ryiza ry’uguhagarika tirosinase), vyose hamwe bikaba ari ibikoresho bine.

Itsinda rya 2:Ivyatsi biva mu bimera, harimwo ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi (birimwo 4% vya Licochalcone A), ifu y’ivyatsi vy’ivyatsi vy’ivyatsi (birimwo SOD), n’ifu y’ivyatsi vy’ivyatsi vyera (birimwo dihydro{1}}/tetrahydro{2}}lycopene), vyose hamwe ni ibikoresho bitatu.

Agaciro ka IC50 k'ibikoresho vyose vy'ibanze yerekanwa mu ndome ya 2.

Hashingiwe ku mibare ya IC50, igikorwa co kugereranya c’uguhagarika tirosinase c’iyo migwi ibiri kirerekanwa ku bishushanyo 9 na 10. Mu mugwi wa 1, igikorwa co guhagarika tirosinase ca Licochalcone A ni incuro 1,4 c’ica glutathione, incuro 3 c’ica kojic acid times, n’ica 14. Mu mugwi wa 2, igikorwa co guhagarika tyrosinase c’ivyatsi vy’ivyatsi vy’umukara vy’i LicoSnow ni incuro 11 z’ifu y’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vy’ivyatsi vyera incuro 6.930.

Ivyemezo vy'ubuvuzi vy'ukwera mu kanwa hakoreshejwe Licorice

Naho ingaruka zo kwera za Licochalcone A zamaze igihe kirekire zemewe n’abahinga kandi zikaba zirushiriza guhabwa agaciro mu bijanye no kwitaho urukoba, nta nyigisho z’ubuvuzi z’abantu zasohowe ku ngaruka zayo zo kwera mu kanwa zavuzwe. Igikoko citwa LicoSnow (kirimwo 4% vya Licochalcone A) kizuza neza na neza ico kinogo.

Huasheng Ingredients, ifatanije n'ikigo kizwi cane co gupima abantu, bakoze igerageza ry'abantu ry'ukwezi kumwe ryari rigizwe n'abantu 34 (abagore b'imyaka 25–50) [5]. Abaje muri iyo nama bariye mu kanwa imigera 100 y’umuti w’ivyatsi vy’umukara vyitwa LicoSnow ku musi (irimwo imigera 4 ya Licochalcone A). Ingaruka zo kwera zasuzumwe biciye ku bipimo bishingiye ku bikoresho n’ibibazo. Ivyo vyavuye muri iryo gerageza ni ibi bikurikira:

Kugabanya ibara ry’urukoba rwo mu maso (16%↓):
Inyuma y’imisi 28 umuntu anywa, uburebure bw’ibara ry’uruhanga bwagabanutse buva kuri 19,87% buja kuri 16,65%, ni ukuvuga ko hagabanutse 16,21% (p=0.004), vyerekana ko hariho itandukaniro rikomeye imbere n’inyuma y’ugufata ibiribwa. Igereranyo ry'ibara ry'uruhanga ry'abaje mu nama ryerekanywe ku gishushanyo ca 11.

Igishushanyo ca 11: Impinduka mu bijanye n’ibara ry’uruhanga; ibubamfu: imbere yo gufungura, iburyo: inyuma yo gufungura

Ukwongerekana kw’umuco w’urukoba (21%↑):
Inyuma y’imisi 28, umuco w’urukoba rwo mu maso waraduze uva kuri 4,0% uja kuri 4,84%, ni ukuvuga iterambere rya 21,00% (p=0.014), vyerekana itandukaniro rikomeye imbere n’inyuma y’ugufata ibiribwa. Igereranyo ry'urukoba rw'abaje mu nama ryerekanywe ku gishushanyo ca 12.

Igishushanyo ca 12: Impinduka mu gukayangana kw’urukoba rwo mu maso; ibubamfu: imbere yo gufungura, iburyo: inyuma yo gufungura

Kugabanya ibara ry'inyuma y'-UV (15%↓):
Imishwarara y’ubuhinga bwa UV yashizwe ku migongo y’abaje muri iyo nama kugira ngo haboneke ahantu ho gutera ibara ry’urukoba. Haciye imisi ibiri inyuma y’uguterwa n’imishwarara, ugukwiragira kw’ibara ry’umubiri kwagereranywa kugira ngo hasuzumwe ibara ry’umubiri ry’inyuma y’-UV. Ingero zafashwe mu ntango y’ugutera ivyatsi (imishwarara D-2, ingero ya D0) no mu mpera (imishwarara D28, ingero ya D30). Inyuma y’imisi 28, agaciro ka melanine mu bice vy’ibara ry’agahama karagabanutse kuva kuri 99 gushika kuri 84, ivyo bikaba vyagabanutseko 15,15% (p < 0,001), vyerekana ko hariho itandukaniro rikomeye imbere n’inyuma y’ugufata ibiribwa.

Kugabanya ugutukura kw’urukoba (28%↓):
Inyuma y’imisi 28, agaciro k’ugutukura (agaciro ka a*, agaciro kanini kerekana urukoba rutukura cane) k’umugongo karagabanutse kuva kuri 10,70 gushika kuri 7,69, ni ukugabanya 28,13% (p < 0,001), vyerekana itandukaniro rikomeye imbere n’inyuma y’ugufata imiti.

Ugutera imbere kw’urukoba muri rusangi (≈90% vy’abaje mu nama bemeye):
Inyuma y’imisi 28, hafi 90% vy’abaje muri iyo nama bavuze ko urukoba rwabo muri rusangi rwateye imbere, nk’urukoba rwabo rwari ruringaniye kandi rukayangana, urukoba rwabo rwarakayangana cane, kandi rwagabanutse gushobora guhinduka urukoba canke gutukura.

Umwirondoro mwiza w'umutekano:
Nta n’ibintu bibi vyabonetse mu kiringo c’igerageza.

Ivyerekeye:
[1] Ikigo c’ubushakashatsi ca Boguang.2025 Ubushinwa Ubwiza bw'Akanwa Isoko Raporo y'Ubushakashatsi.
[2] Chen J, Yu X, Huang Y.Uburyo bwo guhagarika glabridine ku tirosinase.Igice ca A: Igishushanyo c'ibinyabuzima n'ibinyabuzima . 2016 Ugushyingo 5; 168: 111-117.
[3] Raporo y’igerageza yasohowe n’Ikigo c’Igerageza ca Shenzhen 863.
[4] Raporo y’urubanza rw’abantu yasohowe n’ishirahamwe Huace Testing.